The present-day geography of the population distribution in Siberia is examined. Evidence for a linkage of the human settlement pattern with the climatic-comfort conditions (spanning the area from the Arctic coast to the semi-deserts in the south of Siberia) is presented. A detailed study is made of the demographic situation. The number of people living in different natural-climate zones of Siberia, and the number of people living in areas with different levels of environmental pollution are calculated. A sociogeographical analysis is made of the man-natural environment interaction for different stages of development ranging from the utilization of the natural environment as the source of life resources of small (indigenous) peoples (the Evenki, and the Tofalars) to the utilization of the natural environment largely for waste disposal around industrial-urbanized settlements. The report is illustrated with a map titled “Demo-ecological regionalization of the Asian part of Russia).