This study focuses on the influence of weather and climate on malaria occurrence based on human-biometeorological
methods was carried out in Ondo State, Nigeria using meteorological and malaria dataset in the state for the period from 1998 to 2008.
In addition, sea surface temperatures (SSTs) over equatorial Pacific Ocean were integrated in the analysis. The association between
each of the meteorological-biometeorological parameters and clinical-reported malaria cases was examined by using Poisson
distribution and log as link function between the two categories of dataset. The next step was the building of a model by using Poisson
multiple regression models (GLMs) in order to know the weather variables that lead to statistically changes in clinical-reported malaria
cases. The study revealed that an increase of 1 m·s-1 of wind speed can lead to an increase of about 164% and 171% in the monthly
occurrence of malaria at 95% confidence interval in derived savanna and humid forest zone respectively. Also, an increase of 1 ºC in air
temperature and sea surface temperature is associated with 53.4% and 29% increase in monthly malaria occurrence (CI: 95%) in
derived savanna while an increase of 1 ºC in air temperature and sea surface temperature is associated with 56.4% and 15.4% increase
in monthly malaria occurrence at 95% confidence interval in humid forest zone of Ondo State.