Despite the growing number of studies and research projects on climate change adaptation, only a few have examined the gender and cultural dynamics of the adaptation process. Inequality has been identified as a major indicator of the vulnerability of individuals and groups; nevertheless, the gender and cultural aspects of inequality have not received much emphasis. The present article attempts to analyze the influence of gender and cultural relations on the process of climate change adaptation by presenting a study of Dalit and Lama households in the mountainous Humla District of Nepal. The inhabitants of Humla have been experiencing a shift in the monsoon season, a decrease in snowfall, and longer dry periods, with adverse effects on their livelihoods. The main focus of this article is to highlight the cultural, social, and economic dependency of the Lama and Dalit ethnic groups and to examine whether processes of adaptation exacerbate or alter gender inequalities and intercaste dependencies.