As the AIDS/HIV epidemic grows exponentially in Tanzania, the number of children who are orphaned due to this illness has increased in alarming proportions. Utilizing a preliminary exploration of a case study, this article explores a unique, collaborative, grassroots model of comprehensive community care. Orphans International Tanzania (OIT) operates a unique family preservation and support program, the Family Care Program, which aims to maintain orphaned children in home environments with access to education, basic medical care, and good nutrition. Incorporating a strategic international agency/community-based nongovernment organization partnership design and an internationally recognized family support model, comprehensive services are provided to children and their caregivers. This article provides information on impact of HIV/AIDS on Tanzania, illustrates the components of the program model, highlights critical community partnership development, and describes its influence on the children, their kinship caregivers and the community in general. Implications for replication in other communities impacted by HIV/AIDS are provided.