Pregnant women’ health during pregnancy can be maintained by self-care practices. Some factors are indicated as predictors of self-care behaviors during pregnancy. Identifying the predictors of self-care with a theoretical framework is needed to understand and to improve self-care behaviors during pregnancy. This study aimed to identify predictors of pregnant women’ self-care behaviors in Garut district. Pender’s Health Promotion Model was used as the guideline. A cross-sectional survey design was used in this study with multistage sampling technique. The data were collected using self-administrated questionnaire from 263 pregnant women during October 2014. The results showed that 76.4% pregnant women had a fair level of self-care behaviors (Mean 64.14; SD= 5.952). Factors associated with self-care behaviors were knowledge of self-care, perceived benefits of self-care, perceived self-efficacy in self-care, and social support satisfaction (r = .130, r =.27, r = .438, r = .312, respectively). Regression analysis revealed perceived self-efficacy in self-care, social support satisfaction, and knowledge of selfcare were accounted for 25% of the variance in the self-care behaviors of pregnant women in Garut District. The finding suggested promoting self-care behaviors among this group by improving their self-efficacy in self-care, social support satisfaction, and knowledge of self-care.