Labor migration and marital dissolution both contribute to family separation and, through separation, affect children's decisions about education and work. This paper compares the impact of different types of family separation, including labor migration and marital dissolution, on educational enrollment and work participation among older adolescents in Mexico. It also compares the educational expectations, especially those of younger left-behind children in Mexico depending on different types of family separation. Using the nationally representative 2005 Mexican Family Life Survey, I first compared children aged 15-18 who lived in non-migrant, twoparent households with children who experienced labor migration and children who lived in lone-parent households. Both children living in households of family separation are less likely to attend school, even though the results are not statistically significant when further controlling for socioeconomic status. In addition, children living in migrant households are more likely only to work without enrolling in school, and they are also more likely to report neither work nor schooling. Children living in single-parent households are more likely to combine school and work. In terms of educational expectations, after identifying who stays and who leaves the household in both types of family separations, I find that exposure to migration (either sibling migration or paternal migration), is negatively associated with aspirations for postsecondary education. Children ages 11-14 who attended school, and who lived in households with migrating members, were even less likely to aspire to college than were children living in single-mother households. In addition, and surprisingly, children living with divorced/separated mother were more likely to aspire to postsecondary education.