(Aim) Unilateral sensorineural hearing loss is a brain disease, which causes slight morphology within brain structure. Traditional manual method can ignore this change. (Method) First, we used dual-tree complex wavelet transform to extract features. Afterwards, we used kernel principal component analysis to reduce feature dimensionalities. Finally, multinomial logistic regression was employed to be the classifier. (Result) The 10 times of 10-fold stratified cross validation showed our method achieved an overall accuracy of 96.17 ±± 2.49%. The sensitivities of detecting left-sided sensorineural hearing loss, right-sided sensorineural hearing loss, and healthy controls were 96.00 ±± 2.58%, 96.50 ±± 2.42%, and 96.00 ±± 3.16%, respectively. (Conclusion) Our method performed better than five state-of-the-art methods.