A cross-sectional study was conducted to determine the abattoir prevalence of bovine fasciolosis and its associated risk factors in Adigrat municipal abattoir. The current finding revealed that the overall abattoir prevalence was 21.50 % (112/522). Similarly, the abattoir prevalence of the parasites in female and male also showed it was 22.2% (2/ 9) and 20.50% (105/513) for F. hepaticaand 1% (5/513) and 0% (0/9) respectively. At the same time the abattoir prevalence of the parasites in adult and young for F. hepaticawas 20.9% (104/498) and 12.5% (3/24) but that of F.giganticawas 1% (5/498) and 0% (0/24). The abattoir prevalence of the two parasites between sex and age was not statistically significant. Similarly the abattoir prevalence in local and cross breeds were also determined and it was 19% (80/421) and 26.7% (27/101) for F. hepatica and 1.2% (5/421) and 0% (0/101) for F. gigantica respectively. Even though, such variation of prevalence between local and cross breeds exist it was not statistically significant (P>0.05). In addition, animals originated from highland and lowland has the prevalence of 21.7% (107/494) and 0% (0/28) for F. hepatica and 0% (0/494) and 17.9% (5/28) for F.gigantica respectively. The difference of the prevalence between highland and lowland was statistically significant (P<0.05). The current finding also showed the prevalence of F.hepatica in poor, medium and good body condition animals was 46.7% (7/15), 19.4% (79/407), and 21% (21/100) respectively but that of F. gigantica was 0% (0/15), 1%( 4/407) and 1% (1/100) respectively. This result also showed the difference of the prevalence among the different body condition was not statistically significant (P>0.05). The current finding showed fasciolosis is the most common and economical parasitic disease affecting cattle in the region hence, control strategies should be designed to minimize the prevalence of the infection via deworming of animals, drainage of swampy areas and practicing of zero-grazing and application of molluscide drugs in the environment.