Information Communication Technologies (ICTs) are viewed as important tools in preventing global epidemics through facilitation of rapid collection and dissemination of information, interaction and communication between user groups and inter-agency collaborations. In the African context, use of ICTs for health purposes has become particularly critical due to disease burden and the significant erosion of healthcare infrastructure amidst limited human and financial resources, which makes most of the population vulnerable to health threats. When practiced appropriately and with the necessary guiding policies and resources in place, ICTs have great potential to improve health service efficiency, expand or scale up treatment delivery to thousands of patients in developing countries, and improve patient outcomes. The goal of this chapter is to explore the use of ICTs in HIV/AIDS Communication in Kenya, one of the most impacted countries in the African region.