Background: Chlamydia infections in women cause pelvic inflammatory disease, which often results in devastating
consequences of infertility, ectopic pregnancy, or chronic pelvic pain. The infection is largely asymptomatic.
Objective: To determine the seroprevalence of Chlamydia trachomatis in Enugu, South Eastern Nigeria.
Materials and Methods: A population-based prospective study comprising female residents of Enugu, South
Eastern Nigeria. Indirect solid phase enzyme immunoassay of Chlamydia antibodies was done using ImmunoComb
C. Trachomatis IgG Kit (Orgenics).
Results: The population comprised 136 female undergraduate students and 150 non-student women. The overall
prevalence of C. trachomatis in the population studied was 29.4%. The percentage of subjects who admitted to be
having multiple sexual partners was higher among the student population (71.2%) compared to those from the nonstudent
population (28.8%). The highest percentage of seroprevalence was 28 (33.3%) in the age group of 20-24
years for the student population and 18 (21.4%) in the age group of 25-29 years for the non-student population. The
highest seroprevalence of C. trachomatis antibodies (69.0%) in both populations was observed in females without
any history of infection. Females that had pelvic inflammatory disease, sexually transmitted infection, and secondary
infertility assayed for C. trachomatis had seroprevalence levels of 19%, 9.5%, and 2.4%, respectively. There was a
positive correlation between positive Chlamydia assay and the type of subject population (student or non-student) with
r2
value of 1.55 at P < 0.01.
Conclusions: C. trachomatis infection is largely underdiagnosed and remains a silent disease in the apparently healthy
population of Enugu, South eastern Nigeria.