Many efforts have been made to determine and explain differential gender performance on large-scale mathematics assessments. A well-agreed-on conclusion is that gender differences are contextualized and vary across math domains. This study investigated the pattern of gender differences by item domain (e.g., Space and Shape, Quantity) and item type (e.g., multiple-choice i items, open constructed-response items). The U.S. portion of the Programme for International Student Assessment (PISA) 2000 and 2003 mathematics assessment was analyzed. A multidimensional Rasch model was used to provide student ability estimates for each comparison. Results revealed a slight but consistent male advantage. Students showed the largest gender difference (d = 0.19) in favor of males on complex multiple-choice items, an unconventional item type. Males and females also showed sizable differences on Space and Shape items, a domain well documented for showing robust male superiority. Contrary to many previous findings reporting male superiority on multiple-choice items, no measurable difference has been identified on multiple-choice items for both the PISA 2000 and the 2003 math assessments. Reasons for the differential gender performance across math domains and item types were speculated, and directions of future research were discussed.