In this paper we present the initial insight into the ethnic minorities entrepreneurship in Estonia with a focus on the Russian-speaking minority entrepreneurial activities. Based on a survey of various theoretical concepts presented in the opening section, a generalized framework featuring 5 dimensions emerging as requiring greater attention in defining the level of ethnic minorities entrepreneurial activities is introduced. In an effort to explain the currently existing specific social, economic and regional problems related to the Russian-speaking minority, the retrospective historical review was employed. Through a content analysis of lately published empirical and qualitative researches on entrepreneurship, cross-cultural issues and integration, the cultural, ethno-psychological and motivational differences with Estonians were examined. The preliminary results suggest that culturalmotivational differences exist, and specific potential obstacles for starting up an ethnic minorities business such as shortage of financial sources, insufficient command of the Estonian language and a lack of required managerial, marketing, financial and other knowledge, qualifications and skills might have a significant impact on the level of entrepreneurial activity.