Every human being is driven by his/her desire to reach his/her needs, whereby the needs evolve to more ambitious needs once the most fundamental needs have been achieved. To reach more ambitious needs, accommodating socio-economic infrastructures and appropriate government support are required. Based on various surveys, this paper examines the needs hierarchy of Bangladeshi people as well as the main hindrances for not reaching higher up needs in Bangladesh. It analyzes the motivational factors of Bangladeshi employees and looks into the possibility and desirability of employees to become entrepreneurs in Bangladesh. Linking Bangladesh’s needs hierarchy, employee motivation and entrepreneurship in Bangladesh, the paper concludes with suggestions for measures that should be taken in an integrated way by individuals, family, social institutions and government to enable and encourage entrepreneurship in Bangladesh.