In this article, I investigate the concept, social entrepreneurship, as a potential lever in economic and social transformation of the poorest-of-the-poor community of Nellmapius township, east of Pretoria, South Africa. I identify definitions of 'entrepreneurship' and 'social entrepreneurship', and delve into the historical development of the concept 'entrepreneur'. South Africa is in an era where it needs more new venture creation. Hence, I have studied new venture formation, especially from the perspective of Schumpeter's theory of ways of forming a new firm. South Africa lags behind in new venture development compared to other developing countries; I investigated the causes behind this and suggest remedies to address this. Postfoundationalist practical theology is seen as a way of doing theology in the midst of those who suffer poverty and lack. The methods of this approach are dealt with in this article, which also asks what theology can bring to the table of interdisciplinary engagement?