This study described how children in the Cape Coast Metropolitan Area of Ghana are knowledgeable in HIV/AIDS issues as well as their attitude to the disease and People Living with AIDS (PLWAs). It also sets out some measures to be adopted and implemented on how children could be properly integrated in the fight against the pandemic. Three study areas namely, OLA community in Cape Coast (urban), Effutu (semi-urban) and Effutu Mampong (rural) were purposively selected for the study. Four hundred and seventy-six respondents aged 9-13 were drawn from the three public primary schools in the study sites. Primary data were sourced from individual interview schedules, essays and sketches. Most of the qualitative data as captured in the individual interview schedule were drawn from the Ghana Demographic and Health Surveys (GDHS) and analysed using the Statistical Product for Service Solutions (SPSS Version 16) software. The qualitative data were collected from respondent’s essays and sketches on the pandemic. They were compiled and summarised manually. Fifty one per cent of the respondents were females. All the respondents expressed some knowledge in the HIV/AIDS pandemic. Teachers (47.5%) were by far the most important source of information on HIV/AIDS to the respondents in all the three study sites. Other sources mentioned were the radio, friends, books and the television. The results of this study indicate that HIV/AIDS prevention methods are widespread including avoiding unprotected sexual intercourse and non-sharing of sharp objects. Respondents also had some misconceptions on the spread of HIV/AIDS including transmission through mosquito bites, sharing food with an infected person, through witchcraft, a curse or other supernatural means. Most of the respondents thought they were not at risk of contracting the virus that develops into AIDS. Majority of the respondents, irrespective of sex, age or residence, were not willing to purchase fresh vegetables from a known HIV/AIDS patient nor were they prepared to disclose to a third party the identity of an HIV/AIDS infected family member. It is recommended that future interventions on the disease should focus on attitudinal or behavioural change. Teachers also should continually educated on current trends of the disease to enable them educate the young ones