This paper analyzes an independent research project conducted in Ghana. Findings provide a contextual situation analysis of orphans and vulnerable children (OVC) within Greater Accra, Ghana, including a critical examination of early childhood care and development (ECCD) 1 as a response to support OVC and their communities. It examines efforts and challenges characterizing the OVC situation in the Ghanaian context including examples of holistic interventions of early childhood care and education (ECCE), focusing on early childhood development (ECD) practices and programs in existence. Ghana’s OVC situation; although not as severe as other African nations, has grown due to the HIV and AID’s epidemic and changing migration patterns from rural to urban environments. Other influences include social and economic factors which have caused a growing number of children to require care and support outside of their immediate or extended family home, creating a population of vulnerable children. According to a 1999 report from the Ministry of Health (MOH) and the National AIDS Control Program (NACP), there will be an increase in Ghanaian orphans to more than 603,000 in 2014 (MOWAC and UNICEF, 1997-2005).