The purpose of the study is to assess the search for mainstreaming climate change adaptation into regional planning of least developed countries (LDCs) and draw strategy implications for regions in Bangladesh. The findings of the study revealed that national adaptation programme of action (NAPAs) in least developed countries were being gender-blind and failed to be properly implemented. Least developed countries should therefore do more to prepare for ongoing and future climate changes focusing on actions that are no-regrets, multi-sectoral and multi-level, and that improve the management of current climate variability. Strengthening capacities to use climate information, enabling locally appropriate responses, screening climate risks, assessing risks and adaptation options, starting with existing policies and plans, broadening constituencies beyond environment agencies, managing strategy conflicts, learning from projects and recognizing their limitations, monitoring and learning are the foreseen strategic actions by regions in Bangladesh for effective mainstreaming of climate change adaptation into regional development planning in the years to come.