A cross-sectional study based on the secondary data of 18 Demographic Health Surveys carried out in Sub-Saharan Africa was conducted to assess the protective effect of male circumcision from HIV infection and STDs. Information on 70,554 males aged 15-59 years was extracted. The association between circumcision and HIV infection and STD symptoms (Genital discharge or ulcer/sore) was assessed using logistic regression. Un-circumcision was significantly associated with risk of HIV with odds ratio of 4.12 (95%CI: 3.85-4.42). The association was even more significant, 4.95 (95%CI: 4.57- 5.36), after adjustment was made for number lifetime sexual partners and socio-demographic variables. The risk associated with un-circumcision is significantly lower among younger men aged 15-29 years than older age categories. However, circumcision found to have no association with the symptoms of STDs. The study concluded that male circumcision can be considered as a way of reducing the spread of HIV infection (Afr. J. Reprod. Health 2010; 14[2]: 105-113).