Consumerist Culture oriented economic development, commercialisation of medical profession and sexist biases in our society, combined together have created a sad scenario of ‘missing girls’. Global comparisons of sex ratios shows that sex ratios in Europe, North America, Caribbean, Central Asia, the poorest regions of sub Saharan Africa are favourable to women as these countries neither kill/ neglect girls nor do they use New Reproductive Technologies (NRTs) for production of sons. Deficit of women in India since 1901 is a result of violence and discrimination against women over the life cycle. From womb to tomb- female infanticide, ante natal sex selection, neglect of girl child in terms of health and nutrition, child marriage and repeated pregnancy are taking heavy toll of girls’ lives. Prenatal Diagnostic Techniques Act was enacted in 1994 as a result of pressure created by Forum against Sex-determination and Sex-preselection. But it was not implemented. After another decade of campaigning by women’s rights organisations and public interest litigation filed by CEHAT, MASUM and Dr. Sabu George, The Pre-natal Diagnostics Techniques (Regulation and Prevention of Misuse) Amendment Act, 2002 received the assent of the President of India on 17-1-2003. The Pre-Natal Diagnostic Techniques (Regulation and Prevention of Misuse) Amendment Rules, 2003 have activated the implementation machinery to curb nefarious practices contributing for missing girls.