The earliest refrigerants used were R40, R764, R717, R290 and R600a but these had drawbacks of flammability, toxicity, unpleasant smell as well as posing a danger of leakage through the shaft seals of compressors. In 1931, these were replaced by CFCs and HCFCs due to safety and reliability concerns. However in 1986, CFCs and HCFCs were confirmed to have an ozone depleting effect hence their use was discouraged under the Montreal Protocol. Manufacturers responded to this call by introducing HFCs on the market with no ozone depleting effect. However, nowadays, there is immense pressure to shift to natural refrigerants after the discovery that the emission of these substances to the atmosphere contributes to at least 20% of the greenhouse gas emissions. The use of synthetic refrigerants has led to the breakdown of stratospheric ozone molecules and emission of greenhouse gases to the atmosphere leading to global warming and global climate change. Today, there is increasing pressure from legislators, business partners and consumers to seek for new methods to achieve cooling that does not depend on global warming working fluids. Therefore, companies are tasked to rethink established solutions and implement environmentally friendly yet economically sensible technologies to seize their individual eco-advantage. For that matter, the use of refrigerants free of ozone depleting and global warming characteristics in Heating, Ventilating and Air Conditioning continues to take a central role in measures to reduce greenhouse gas emission. This study aims at investigating the application of environmentally friendly solutions in refrigeration applications of Uganda with the main emphasis on natural refrigerants. This has been accomplished by ascertaining the current status of refrigeration in Uganda as well as modeling and simulation of the available systems and comparison of the results with those of recommended systems.