The increasing use of family planning methods seems to be the intermediate determinant which mostly influences the fertility decline in developing countries, and in particular in those countries which are in an advanced phase of demographic transition such as Egypt. Moreover large countries, like Egypt, are characterized by very different geographical realities and even by strong regional heterogeneities. The aim of this study is the analysis of the determinants of contraceptive use in Egypt, with particular reference to the differentials due to the socio-economic context and to the area of residence. To estimate each individual and regional factors’ effect on contraceptive use, a logistic two-level random intercept model is fitted to EDHS 2000 data; the use of a multilevel analysis is suggested by the two-level data structure: the first level units are the women, the second level units are their regions of residence.