Abstract: Background: Although there is a high awareness about pregnancy prevention methods among youth, in Ethiopia, the problems are still rampant which indicates lack of comprehensive knowledge about pregnancy among youths. So, having indepth and comprehensive knowledge about pregnancy and associated factors has a paramount importance. Objectives: the main aim of this study is to assess comprehensive pregnancy knowledge level and associated factors among out of school youths in Wayu Tuka district of east Wollega zone. Methods: A quantitative community based cross-sectional study design was used. Data were collected using structured questionnaire from a total of 625 respondents selected systematically from 6 randomly selected kebeles of the district. Data was entered using EPI data version 3.02 and analysed by using SPSS version 16.0. To ascertain the association between dependent and independent variables, binary logistic regression was performed and variables with p-value of less than or equal to 0.3 at binary were entered into multivariable logistic regression analysis. Variables with p-value of