A case study research was conducted in the city of Puerto Carreño, Colombia to assess adaptive capacity for the Farmers’ community and indigenous people to face climate change. Some of these inhabitants understand these changes in the weather as natural processes, others as climate change. The major finding of this study was that these communities started perceiving changes in the weather between the years of 2010 and 2011. These changes refer to the increase in the temperature and alteration of the rainy and dry seasons. Another important finding is related to the new economic activities, which are seen by some participants as contributors to the climate change in the region. The results suggest that these two communities have been and will continue feeling changes in the weather in the Orinoco region. Although these communities possess some of the tools necessary for adaptive capacity to climate change, these tools are not strong enough yet.