Far too many people in urban Ghana live without access to safe drinking water and this is a primary determinant of continuing poverty. Using questionnaire survey and key informant interviews, this study explored the situation of households’ access to potable water supply in the Wa Municipality, a low-income urban area in north-west Ghana. This study highlights several important issues on access to water supply focusing on availability, accessibility and cost. A clustered sample of residential areas of the municipality was employed and the study was able to examine spatial disparities in access to water supply. The results indicate that access to potable water supply in the municipality is generally high as only 13 percent of households depend on open wells as their main source. Also, the private sector (individuals and non-governmental organizations) are major players in public water supply in the municipality. In spite of the progress made in access to potable water supply, distance and cost of water remain serious challenges confronting households. The study recognizes that private individuals create additional water facilities to augment public supplies, but the positive impacts on health and livelihoods could be greater if access to finance could be facilitated. Most importantly, water supply improvement strategies should incorporate an integrated vision, which sees adequate and quality water both as a goal in itself and as a contributor to economic and social development through gains in public health.