The Governments of Ghana’s commitment to financial discipline, accountability, transparency, ethical conduct and effective management of public procurement have been pursued for years. One of numerous efforts is seen with the promulgation of the Public Procurement Act, 2003 (Act 663) to regulate public spending. However, since the introduction of the act, it aims have not been fully realized in certain parts of the country including the Brong-Ahafo Region. The objective of this study was to investigate the effects of the Public Procurement Act (Act 663) on Public Financial Management of MMDAs in the Brong – Ahafo Region. The causes of delay in the implementation of procurement activities as well as measures required to improve procurement processes were looked at. Quantitative research design was employed. Purposive sampling technique was used to recruit 50 procurement personnel working in the various MMDAs in the Brong Ahafo Region. Structured questionnaire was administered to them. Out of 50 questionnaires distributed, 48 were received and analyzed using Statistical Package for Social Scientist (SPSS) version 16. The outcome of the studies revealed that the act has the effect of delaying procurement processes in the region. That notwithstanding, it has considerably helped effectively manage government resource in procuring goods, works and services in the region. The only challenge found was that the capacity (i.e. the academic qualification) of most of the procurement personel in procurement was low. It was consequently recommended that the District and municipal assemblies should organize training courses and workshops to build up the capacity of the staffs. Adoption of e- procurement tools (information communication technology) was also recommended.