The present study was aimed at establishing relationships between CD4 cell counts and various clinical presentations commonly associated with HIV/AIDS patients in Cameroon. This study was made up of retrospective and prospective phases, carried out among HIV positive cases seen at the Internal Medicine Service of the University of Yaounde Teaching Hospital. After informed consent, data was collected from participants. This included information on demographic and various clinical signs and symptoms associated with HIV/AIDS as well as CD4 cell count results. The population studied consisted of 556 positive cases, 58% females (323) and 42% males (233). HIV positive status were known among 89.9% of the cases following episodes of ill health while Voluntary Counselling and Testing (VCT) diagnosed HIV only among 5% of them. Cases were grouped into clinical categories as follows: A 14.5%, B 33.2%, C 28.2% and 24.1% were not classified. Clinical signs and symptoms were dominated by anaemia 61%, pneumonia 34.5%, meningitis 9.9%, unexplained fiver 34.4%, loss of weight more than 10%, 30.4%, tiredness 21.2 %, diarrhoea 14.2% and cough 11.1%. In all, 29.6% of the subjects had CD4 cell counts less than 100 cell mm-3, while 43.3% of them had counts below 200 cells mm-3. Statistically significant associations were established between low CD4 cell counts and various pathologies as follows: tuberculosis p<0.01, oral candidosis p<0.02, kaposi`s sarcoma p<0.04, herpes zoster p<0.002 and genital herpes p<0.05. The present study shows that majority of the subjects get to know their HIV status very late, already developing clinical signs and symptoms of AIDS with very low CD4 cell counts. There is need for improvement of early HIV diagnosis strategy through education and voluntary counselling among populations in Africa.